IL-33trap-mediated IL-33 neutralization does not exacerbate choroidal neovascularization, but fails to protect against retinal degeneration in a dry age-related macular degeneration model

Author:

Van Hove IngeORCID,Van Bergen TineORCID,Etienne Isabelle,Holgado Aurora,Afonina Inna S.ORCID,Beyaert RudiORCID,Feyen Jean HM.,Hu Tjing-Tjing

Funder

Universiteit Gent

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology

Reference87 articles.

1. Critical roles of IL-33/ST2 pathway in neurological disorders;Abd Rachman Isnadi;Mediators. Inflamm.,2018

2. Conflicting vascular and metabolic impact of the IL-33/sST2 axis;Altara;Cardiovasc. Res.,2018

3. IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment;Augustine;J. Neuroinflammation,2019

4. Aflibercept: a review of its use in the treatment of choroidal neovascularization due to age-related macular degeneration;Balaratnasingam;Clin. Ophthalmol.,2015

5. Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina;Balser;J. Neuroinflammation,2019

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