SARS-CoV-2 spike E484K mutation reduces antibody neutralisation

Author:

Jangra Sonia,Ye Chengjin,Rathnasinghe Raveen,Stadlbauer Daniel,Krammer Florian,Simon Viviana,Martinez-Sobrido Luis,García-Sastre Adolfo,Schotsaert Michael,Alshammary Hala,Amoako Angela A.,Awawda Mahmoud H.,Beach Katherine F,Bermúdez-González Maria C.,Chernet Rachel L.,Eaker Lily Q.,Ferreri Emily D.,Floda Daniel L.,Gleason Charles R.,Kleiner Giulio,Jurczyszak Denise,Matthews Julia C.,Mendez Wanni A.,Mulder Lubbertus C.F.,Russo Kayla T.,Salimbangon Ashley-Beathrese T.,Saksena Miti,Shin Amber S.,Sominsky Levy A.,Srivastava Komal

Funder

JPB Foundation

NIAID

NCI

Publisher

Elsevier BV

Subject

Virology,Infectious Diseases,Microbiology (medical),Microbiology

Reference5 articles.

1. Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants;Weisblum;eLife,2020

2. Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies;Greaney;Cell Host Microbe,2021

3. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants;Wang;bioRxiv,2021

4. mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants;Wu;bioRxiv,2021

5. The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera;Rathnasinghe;medRxiv,2021

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