Enhanced protein degradation by intracellular delivery of pre-fused PROTACs using lipid-like nanoparticles

Author:

Chen Jinjin,Qiu Min,Ma Feihe,Yang Liu,Glass Zachary,Xu Qiaobing

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference18 articles.

1. Small-molecule PROTACS: New approaches to protein degradation;Toure;Angew. Chem. Int. Ed.,2016

2. Proteolysis-targeting chimeras: induced protein degradation as a therapeutic strategy;Ottis;ACS Chem. Biol.,2017

3. Small-molecule PROTACs, new approaches to protein degradation;Toure;Angew. Chem. Int. Ed.,2016

4. Structural basis of PROTAC cooperative recognition for selective protein degradation;Gadd;Nat. Chem. Biol.,2017

5. An oral androgen receptor PROTAC degrader for prostate cancer;Neklesa;Cancer Res.,2017

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