A rapid MS/MS method to assess the deuterium kinetic isotope effect and associated improvement in the metabolic stability of deuterated biological and pharmacological molecules as applied to an imaging agent-Reference-Cited by-同舟云学术

A rapid MS/MS method to assess the deuterium kinetic isotope effect and associated improvement in the metabolic stability of deuterated biological and pharmacological molecules as applied to an imaging agent

Published:2019-08 Issue: Volume:1064 Page:65-70
ISSN:0003-2670
Container-title:Analytica Chimica Acta
language:en
Short-container-title:Analytica Chimica Acta

Author:

Murphy Rhys B.^ORCID,Wyatt Naomi A.,Fraser Benjamin H.,Yepuri Nageshwar R.,Holden Peter J.,Wotherspoon Andrew T.L.,Darwish Tamim A.

Funder

Australian Nuclear Science and Technology Organisation

Publisher

Elsevier BV

Subject

Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference41 articles.

1. Chemical Kinetics;Laidler,1987

2. Using deuterium in drug discovery: leaving the label in the drug;Gant;J. Med. Chem.,2014

3. Deuterated drugs: where are we now?;Timmins;Expert Opin. Ther. Pat.,2014

4. The renaissance of H/D exchange;Atzrodt;Angew. Chem. Int. Ed.,2007

5. Deuterium- and tritium-labelled compounds: applications in the life sciences;Atzrodt;Angew. Chem. Int. Ed.,2018

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