Neuronal overexpression of Alzheimer's disease and Down's syndrome associated DYRK1A/minibrain gene alters motor decline, neurodegeneration and synaptic plasticity in Drosophila
Author:
Funder
University of Oxford
Korea Research Institute of Bioscience and Biotechnology
Kings College London
Publisher
Elsevier BV
Subject
Neurology
Reference69 articles.
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2. DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects;Ahn;Neurobiol. Dis.,2006
3. Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration;Ali;J. Vis. Exp.,2011
4. Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome;Altafaj;Hum. Mol. Genet.,2001
5. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome;Altafaj;Neurobiol. Dis.,2013
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1. DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity;Scientific Reports;2022-09-23
2. Effects of Eph/ephrin signalling and human Alzheimer's disease-associated EphA1 on behaviour and neurophysiology;Neurobiology of Disease;2022-08
3. DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes;Frontiers in Pharmacology;2022-07-19
4. Rational Design and Identification of Harmine‐Inspired, N ‐Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System**;ChemMedChem;2022-01-27
5. DYRK1A role in microtubule-based axonal transport regulates the retrograde dynamics of APP vesicles in human neurons;2021-02-25
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