Simultaneous determination of pradefovir, PMEA and tenofovir in HBV patient serum using liquid chromatography–tandem mass spectrometry and application to phase 2 clinical trial
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry
Reference17 articles.
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2. Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B;Reddy;J. Med. Chem.,2008
3. Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver;Erion;J. Am. Chem. Soc.,2004
4. Liver-targeted drug delivery using HepDirect prodrugs;Erion;J. Pharmacol. Exp. Ther.,2005
5. Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer;Lin;Antimicrob. Agents Chemother.,2006
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3. Simple thin layer chromatography–ultraviolet spectrophotometric method for quality assessment of binary fixed‐dose‐combinations of lamivudine/tenofovir disoproxil fumarate and lamivudine/zidovudine in tablet formulations;Journal of Separation Science;2020-04-06
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