Development and validation of a simple, selective, and sensitive LC-MS/MS assay for the quantification of remdesivir in human plasma

Author:

Nguyen Ryan,Goodell Jennifer C.,Shankarappa Priya S.,Zimmerman Sara,Yin Tyler,Peer Cody J.,Figg William D.

Funder

National Cancer Institute

NIH Clinical Center

National Institutes of Health

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry

Reference23 articles.

1. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial;Wang;The Lancet,2020

2. GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses;Lo;Sci. Rep.,2017

3. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys;Warren;Nature,2016

4. Hinton DM. Emergency Use Authorization (EUA) Of Remdesivir (GS-5734™). Food and Drug Administration, 2020.

5. Hinton DM. Veklury (remdesivir) EUA Letter Of Approval, Reissued 10/22/2020. Food and Drug Administration, 2020.

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