Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus-Reference-Cited by-同舟云学术

Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus

Published:2024-05-16 Issue:5 Volume:105 Page:
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

,Allweiss Lena¹²,Cohen Chari³,Dias Joao⁴,Fumagalli Valeria⁵⁶,Guo Haitao⁷,Harris James M.⁸,Hu Jianming⁹,Iannacone Matteo⁵⁶,Isogawa Masanori¹⁰,Jeng Wen-Juei¹¹,Kim Kyun-Hwan¹²,Kramvis Anna¹³,Li Wenhui¹⁴¹⁵,Lucifora Julie¹⁶,Muramatsu Masamichi¹⁷,Neuveut Christine⁴,Ploss Alexander¹⁸,Pollicino Teresa¹⁹,Protzer Ulrike²⁰¹,Tan Anthony²¹,Tanaka Yasuhito²²,Tu Thomas²³²⁴,Tsukuda Senko⁸,Thimme Robert²⁵,Urban Stephan¹,Watashi Koichi²⁶,Yuan Zhenghong²⁷,Yeh Shiou-Hwei²⁸²⁹,McKeating Jane A.⁸³⁰,Revill Peter A.³¹³²^ORCID

Affiliation:

1. German Center for Infection Research (DZIF), Braunschweig, Germany

2. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

3. Hepatitis B Foundation, Doylestown, PA, USA

4. Laboratoire de Virologie Moléculaire, CNRS Université de Montpellier, Montpellier, France

5. Vita-Salute San Raffaele University, 20132 Milan, Italy

6. Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

7. Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

8. Nuffield Department of Medicine, University of Oxford, Oxford, UK

9. Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA

10. Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

11. Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan, Taiwan, ROC

12. Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea

13. Anna Kramvis Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa

14. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, PR China

15. National Institute of Biological Sciences, Beijing, PR China

16. CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France

17. Department of Infectious Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Hyogo, Japan

18. Department of Molecular Biology, Princeton University, Princeton, NJ, USA

19. Department of Clinical and Experimental Medicine, University Hospital of Messina, Messina, Italy

20. Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany

21. Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore

22. Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan

23. Centre for Infectious Diseases and Microbiology, Sydney Infectious Diseases Institute, The University of Sydney at Westmead Hospital, Westmead, NSW, Australia

24. Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney at Westmead Hospital, Westmead, NSW, Australia

25. Department of Medicine II, University Hospital Freiburg, Breisgau, Germany

26. Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan

27. Key Lab of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, PR China

28. Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC

29. Graduate Institute of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC

30. Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK

31. Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia

32. Department of Infectious Diseases, University of Melbourne, Parkville, Victoria, Australia

Abstract

Since its discovery in 1965, our understanding of the hepatitis B virus (HBV) replication cycle and host immune responses has increased markedly. In contrast, our knowledge of the molecular biology of hepatitis delta virus (HDV), which is associated with more severe liver disease, is less well understood. Despite the progress made, critical gaps remain in our knowledge of HBV and HDV replication and the mechanisms underlying viral persistence and evasion of host immunity. The International HBV Meeting is the leading annual scientific meeting for presenting the latest advances in HBV and HDV molecular virology, immunology, and epidemiology. In 2023, the annual scientific meeting was held in Kobe, Japan and this review summarises some of the advances presented at the Meeting and lists gaps in our knowledge that may facilitate the development of new therapies.

Funder

National Institute of Health

Italian Association for Cancer Research

Japan Agency for Medical Research and Development

Japan Science and Technology Agency (JST) MIRAI program

ERC Consolidator Grant

Ministry of Education

Wellcome Investigator Award

National Institutes of Health

National Science and Technology Council

Italian Ministry for University and Research Grants

Chinese Academy of Medical Sciences Innovation Fund for Medical Science,