Pathological findings and diagnostic implications of a rhesus macaque (Macaca mulatta) model of aerosol-exposure melioidosis (Burkholderia pseudomallei)

Author:

Yingst Samuel L.1,Facemire Paul1,Chuvala Lara2,Norwood David1,Wolcott Mark1,Alves Derron A.3

Affiliation:

1. US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD, USA

2. University of Florida Institute for Therapeutic Innovations, Albany, USA

3. Department of Defense Veterinary Service Activity, Office of the Surgeon General, Arlington, VA, USA

Abstract

Aerosolized Burkholderia pseudomallei, the causative agent of melioidosis, can infect many species of mammals (including humans), causing rapid, severe pneumonia with high mortality. Diagnosis in humans is challenging, as few organisms can be detected in blood or other non-invasive samples. Although it cannot be said that the model is established, studies to date indicate that rhesus macaques may represent a good model of human melioidosis. This is supported by the results of this study. The early progression of meliodosis in the rhesus macaque was studied in an effort to better understand the disease and the application of rapid diagnostic methods. Results indicate that a PCR analysis of key diagnostic samples such as nasal swabs, throat swabs, tracheo bronchial lymph node aspirates and broncho-alveolar lavage may be a useful component of a rapid diagnostic algorithm in case of aerosol exposure.

Publisher

Microbiology Society

Subject

Microbiology (medical),General Medicine,Microbiology

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