Genomic characterization of Sebokele virus 1 (SEBV1) reveals a new candidate species among the genus Parechovirus-Reference-Cited by-同舟云学术

Genomic characterization of Sebokele virus 1 (SEBV1) reveals a new candidate species among the genus Parechovirus

Published:2013-07-01 Issue:7 Volume:94 Page:1547-1553
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Joffret M. L.¹²,Bouchier C.³,Grandadam M.⁴,Zeller H.⁵,Maufrais C.⁶,Bourhy H.⁷,Despres P.⁸,Delpeyroux F.¹²,Dacheux L.⁷

Affiliation:

1. INSERM, U994, Paris, France

2. Institut Pasteur, Unité de Biologie des Virus Entériques, Paris, France

3. Institut Pasteur, Plate-forme Génomique, Paris, France

4. Institut Pasteur, Centre National de Reference des Arbovirus, Unité des Interactions Moléculaires Flavivirus-Hôtes, Paris, France

5. Institut Pasteur, Unité de Biologie des Infections Emergentes, Lyon, France

6. Institut Pasteur, Centre d’Informatique pour les Biologistes, Paris, France

7. Institut Pasteur, Unité de Dynamique des Lyssavirus et Adaptation à l’Hôte, Paris, France

8. Institut Pasteur, Unité des Interactions Moléculaires Flavivirus-Hôtes, Paris, France

Abstract

We determined the genomic features and the taxonomic classification of Sebokele virus 1 (SEBV1), a previously unclassified arbovirus isolated in 1972 from rodents collected in Botambi, Central African Republic. The complete genome sequence was obtained using a deep sequencing approach (Illumina technology) and dedicated bioinformatics workflows for data analysis. Molecular analysis identified SEBV1 as a picornavirus, most closely related to Ljungan viruses of the genus Parechovirus. The genome has a typical Ljungan virus-like organization, including the presence of two unrelated 2A protein motifs. Phylogenetic analysis confirmed that SEBV1 belongs to the parechovirus phylogroup and was most closely related to the Ljungan virus species. However, it appeared clearly distinct from all members of this phylogroup, suggesting that it represents a novel species of the genus Parechovirus.

Publisher

Microbiology Society

Subject

Virology

Reference39 articles.

1. Protein is linked to the 5′ end of poliovirus RNA by a phosphodiester linkage to tyrosine;Ambros;J Biol Chem,1978

2. Prevalence, Types, and RNA Concentrations of Human Parechoviruses, Including a Sixth Parechovirus Type, in Stool Samples from Patients with Acute Enteritis

3. Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.

4. Cleavage site analysis in picornaviral polyproteins: Discovering cellular targets by neural networks

5. Myristylation of picornavirus capsid protein VP4 and its structural significance

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structural plasticity of 2A proteins in the Parechovirus family;2024-04-06

2. Detection of parechovirus A in respiratory, gastrointestinal, and neurological clinical samples of pediatric patients from Panama (2014–2015);Virology Journal;2023-12-19

3. A comparative analysis of parechovirus protein structures with other picornaviruses;Open Biology;2021-07

4. Genomic Characterization of the First Parechovirus in Bats;Virologica Sinica;2019-04-05

5. Ljungan/Sebokele-like picornavirus in birds of prey, common kestrel ( Falco tinnunculus ) and red-footed falcon ( F. vespertinus );Infection, Genetics and Evolution;2017-11