Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs-Reference-Cited by-同舟云学术

Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs

Published:2012-03-01 Issue:3 Volume:93 Page:603-607
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Yoshikawa Rokusuke¹²³,Yasuda Jiro⁴,Kobayashi Takeshi²,Miyazawa Takayuki¹³

Affiliation:

1. Graduate School of Human and Environmental Studies, Kyoto University, Yoshida-Nihonmatsucho, Sakyo-ku, Kyoto 606-8501, Japan

2. Laboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan

3. Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan

4. Department of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan

Abstract

All domestic cats carry an infectious endogenous retrovirus termed RD-114 virus. Recently, we and others found that several live-attenuated vaccines for dogs were contaminated with infectious RD-114 virus. In this study, we confirmed that the RD-114 virus efficiently infected and proliferated well in canine primary kidney cells, as well as three tested canine cell lines. Further, we identified canine ASCT1 and ASCT2, sodium-dependent neutral amino acid transporters, as RD-114 virus receptors. Canine ASCT2 also acts as a functional receptor for simian retrovirus 2, a pathogenic retrovirus that induces immunodeficiency in rhesus macaques. Identification of the canine receptor for RD-114 virus will help in evaluating the risk from vaccines contaminated by the virus.

Publisher

Microbiology Society

Subject

Virology

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