Investigation of Sickle Cell Nephropathy

Abstract

Sickle cell nephropathy is a complication of sickle cell anemia (SCD), a genetically inherited blood disease. It is a genetic disorder characterized by the presence of HbS modified due to amino acid mutation. The mutation causes hemoglobin to assume a sickle shape under certain conditions, leading to various complications such as decreased elasticity, increased hemolysis, and vascular occlusion. Polymerization of HbS in an oxygen-free environment causes organ dysfunction by contributing to vascular occlusion and tissue hypoxia. These sickle-shaped cells can cause blockages in the circulatory system and tissue hypoxia, leading to damage to various organs. Nephropathy is known as one of the common complications of sickle cell disease. Sickle cell nephropathy is generally characterized by impaired renal function, proteinuria, hematuria, hyposthenuria, and sometimes renal failure. Treatment of sickle cell nephropathy focuses on symptomatic supportive treatments, and in advanced cases such as renal failure, kidney transplantation may be required. In summary, sickle cell nephropathy is a condition that causes damage to the kidneys as a result of sickle cell anemia and can lead to serious complications. For these reasons, it becomes important to conduct further research to support the literature.