Genetically modified organisms in urological cancer

Abstract

Genetically modified organisms (GMOs) have become indispensable tools in pre-clinical research for urological cancer. Through genetic engineering techniques, researchers can modify the genetic composition of organisms, enabling the creation of appropriate experimental animal models that provide a deep insight into the mechanisms of tumorigenesis, progression, and potential therapeutic strategies for urological cancer. In this chapter, we provide a comprehensive overview of the current status of research utilizing GMOs in the investigation of prostate cancer, renal cancer, urothelial cancer, and other urological cancers. Topics covered the development of different genetically modified animal models, and the application of these models in urological cancer research. In addition, the limitations of GMOs in cancer research will be discussed.