Abstract
The antioxidant properties of quercetin stem from its ability to neutralize reactive oxygen species (ROS) and counteract oxidative stress, a key contributor to various chronic diseases. Numerous in vitro studies have demonstrated quercetin’s effectiveness in scavenging free radicals and protecting cellular structures from oxidative damage. Beyond its direct antioxidant effects, quercetin also interacts with cellular signaling pathways, influencing gene expression and modulating enzymatic activities associated with oxidative stress. In vivo studies, both in animals and human trials, have provided insights into the bioavailability and physiological impact of quercetin, yet its significance remains underappreciated. This chapter will focus on the mechanisms by which quercetin enters circulation, its distribution in tissues, and the subsequent effects on markers of oxidative stress. Additionally, we will highlight findings from previous epidemiological studies linking quercetin-rich diets to reduced risk of chronic diseases, emphasizing the potential translational significance of these antioxidant properties in real-world health outcomes. In conclusion, this chapter will provide an overview of quercetin’s antioxidant properties and its potential for therapeutic interventions associated with chronic diseases.