Managing COVID-19 Variants: Mapping Data from the International Clinical Trials Registry Platform

Abstract

The COVID-19 pandemic has presented an ongoing global challenge, marked by the emergence of multiple SARS-CoV-2 variants. Effective management of these variants necessitates a comprehensive understanding of their clinical impact and the development of targeted interventions. This study explores the landscape of clinical trials giving a better understanding of the COVID-19 variants registered on the International Clinical Trials Registry Platform (ICTRP). Leveraging data from the ICTRP, we conducted an extensive mapping to assess basic characteristic features of registered clinical trials, while also giving an overview of currently used therapeutics, vaccines, and diagnostic tools specifically tailored to combat SARS-CoV-2 variants. Our analysis also provides valuable insights into the geographical distribution, trial design, and therapeutic modalities targeted at these variants. By synthesizing and visualizing this data, we aim to facilitate global collaboration, resource allocation, and evidence-based decision-making in the ongoing fight against COVID-19 variants. This chapter underscores the significance of the ITCRP registry for understanding the evolving pandemic landscape and highlights the ongoing efforts to confront the challenges posed by SARS-CoV-2 variants. The chapter also highlights essential considerations relevant to the management of COVID-19 variants in low- and middle-income countries with limited health infrastructure.