Utilization of a Fertile Chip in Cases of Male Infertility

Abstract

Infertility is a significant reproductive health issue affecting 10–15% of couples of reproductive age worldwide. The male component adds 30–50% to IVF failure. In the examination of male infertility, sperm count, morphology, motility, and genomic integrity of sperm are crucial factors. Several strategies for generating morphologically and genetically superior sperms for use in IUI and IVF procedures or experimental research have been developed. Density gradient and swim-up approaches are two of the most commonly used applications. As this procedure needs centrifugation, it has been observed that it may have a negative impact on sperm viability, increase oxygen radicals, and result in sperm DNA fragmentation. Inadequacies in sperm extraction procedures may have unfavorable long-term consequences in terms of fertilization success, continuation of pregnancy, and embryo health. Microfluidic sperm preparation is an alternate method for decreasing DNA fragmentation at this stage, despite the fact that it has only been established recently. However, these innovative techniques have little clinical trials. According to studies, sperm sorting chips are user-friendly, inexpensive, and do not require many manual stages.