Abstract
Uveal melanoma (UM) is the most common primary intraocular malignancy with a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The treatment remains challenging for metastatic UM, even though our understanding of UM has advanced. Risk factors for developing UM include ages, skin colors, and genetic mutations. Many therapies that have applied to cutaneous melanoma have little or no success in UM. Various forms and combinations of radiotherapy, phototherapy, and local resection are utilized for advanced cases. The treatment aims to preserve the eye and useful vision and prevent metastases. This chapter aims to introduce the current study for UM.