Author:
Asadbegi (Hamedi) Masoumeh,Komaki Alireza,Amiri Parsa,Asaad Karimi Seyed,Yaghmaei Parichehreh,Ebrahim-Habibi Azadeh,Salehi Iraj
Abstract
Thymol is a natural phenolic compound that is present in various plants; the significant antioxidant activities of Thymol may be helpful in preventing the progress of various oxidative stress-related diseases. Recent studies have confirmed that antioxidant-rich foods play a vital role in the disease prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). We examined the protective and therapeutic effects of Thymol on the Aβ-induced long-term potentiation (LTP) impairments in rats fed a high-fat diet. LTP is a type of synaptic activity that has been thoroughly studied in the hippocampus and is thought to be the neural correlate of learning and memory. If Thymol is protective against AD-related impairments, then natural therapeutic agents based on the structure of Thymol could be used to protect against oxidative stress-related illnesses, such as AD.
Reference78 articles.
1. Asadbegi M, Yaghmaei P, Salehi I, Komaki A, Ebrahim-Habibi A. Investigation of thymol effect on learning and memory impairment induced by intrahippocampal injection of amyloid beta peptide in high fat diet-fed rats. Metabolic Brain Disease. 2017;32(3):827-839
2. Millette D. Short-Term Feeding Effects of High-Fat Diet on Hippocampal Neuroinflammation: Differences among C57BL/6J, C3H/HeN, and C3H/HeJ Mice. Chapel Hill, NC, United States: The University of North Carolina at Chapel Hill; 2012
3. Ganai SA, Banday S, Farooq Z, Altaf M. Modulating epigenetic HAT activity for reinstating acetylation homeostasis: A promising therapeutic strategy for neurological disorders. Pharmacology & Therapeutics. 2016;166:106-122
4. Huang C, Dong D, Jiao Q , Pan H, Ma L, Wang R. Sarsasapogenin-AA 13 ameliorates Aβ-induced cognitive deficits via improving neuroglial capacity on Aβ clearance and antiinflammation. CNS Neuroscience & Therapeutics. 2017;23(6):498-509
5. Majid T, Griffin D, Criss Z II, Jarpe M, Pautler RG. Pharmocologic treatment with histone deacetylase 6 inhibitor (ACY-738) recovers Alzheimer's disease phenotype in amyloid precursor protein/presenilin 1 (APP/PS1) mice. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2015;1(3):170-181