Potential of Ferrite-Based Nanoparticles for Improved Cancer Therapy: Recent Progress and Challenges Ahead

Abstract

Recently, ferrite nanomaterials have emerged as a potent entrant in the biomedical field, especially in diagnosing and treating cancer in various organs because of their low toxicity, favorable magnetic properties, and biocompatibility. The conventional chemotherapy used for cancer treatment suffers from a deep setback because of the associated severe side effects produced in cancer patients during the treatment, such as bone marrow depression, hair fall, kidney damage, heart problems, neurological disorders, and others. Hence, in this context, ferrite nanomaterials provide the benefits of targeted delivery of a cytotoxic anticancer drug(s) to the specific tumor site using an external magnetic field, causing minimal side effects on healthy tissues. Another important benefit of using these nanomaterials lies in their ability to enhance the water solubility of hydrophobic drugs in order to extend the prolonged circulation of drugs in the blood and also to prevent fast renal excretion. Therefore, in this chapter, we will address the recent status and progress of ferrite-based nanomaterials in cancer therapy and will also cover the major challenges that hinder their translation from research to clinic.