Diffuse Large B-Cell Lymphomas: From Morphology to Genomic Profiling

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma in the western world. The classification of these lymphomas has been and continues to be one of the most challenging aspects of this entity. DLBCLs are clinically and morphologically very heterogeneous diseases presenting a barrier to successfully developing adequate classification systems with significant clinical, prognostic and therapeutic relevance. Recent gene expression profiling and next-generation sequencing advances have improved our understanding of the disease. This review will present an up-to-date overview of traditional and modern classification systems in DLBLC, emphasizing newly proposed subgroups based on integrating gene expression profiling and sequencing data.