Affiliation:
1. Amala Cancer Research Centre, India
2. Pushpagiri Institute of medical sciences & Research Centre, India
Abstract
Silver (SN) nanoparticles were re-dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha- Lipoic acid (LA). The nanoparticle - LA complex (SN-LA) was characterized using SEM. SN-LA exhibited DPPH radical scavenging activity in vitro and anti- inflammatory activity against acute and chronic paw models of edema in mice. SN-LA protected mice from whole body gamma radiation induced body weight losses and mortality revealing its radioprotecting capacity. Meanwhile, SN-LA administration to tumour-bearing mice prior to whole body gamma radiation exposure, aided in better tumour growth delay. The results suggest the feasibility in using SN-LA as a therapeutic adjuvant during cancer radiotherapy.
Subject
Electrical and Electronic Engineering,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Biotechnology
Cited by
31 articles.
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