A new methodology for systemic audit of ischemic stroke in the most acute and acute periods of the disease

Abstract

Purpose of the study. Create a methodology for systemic audit of ischemic stroke (IS) in the most acute and acute periods of the disease. Materials and methods. The clinical study included 328 patients with IS (mean age 71,26 ± 0,44 years), who were in the intensive care unit of the neurology department in the most acute and acute periods of the disease. There were 147 men (mean age 69,80 ± 0,66 years), women 181 (mean age 72,45 ± 0,58 years). According to the intensity of ESST disorders, assistive technologies of personalized intensive therapy (IT) were developed, such as homeostasisprovision for eubiotic state, energy-protection for hypoergic dysfunction, energy-resuscitation for hypoergic damage, energy-correction for hypoergic insufficiency, status-protection for hyperergic dysfunction, status-resuscitation for hyperergic damage, status-correction for hyperergic insufficiency. Results. The main parameters of energystructural status (ESST), which characterize the stabilization of the general condition of patients in the most acute and acute periods of IMI, such as cardiac index (CI) in the range of 2,99–3,79 L×min-1 × m-2, oxygen delivery (DO ) at the level of 415–514 ml × min-1 × m-2; oxygen consumption (VO2) in the range of 130–160 ml × min-1 × m-2; basal metabolism (BM) in the range of 916–1134 kcal × day-1 × m-2 and specific peripheral vascular resistance (SPVR) in the range of 29–36 conditional unit. Conclusion. The conducted clinical research allowed to develop assistive technologies of personalized IT, which were used depending on the severity of energy-structural disorders in patients with IS. The use of personalized IT technologies, in accordance with the intensity of ESST recovery, has reduced mortality, the number of complications and the length of stay of patients with IS in the intensive care units of the neurology department.