The use of procalcitonin in patients with pyogenic liver abscesses

Abstract

The results of treatment of 79 patients with pyogenic liver abscesses (AP) were analyzed. Sepsis was diagnosed in 10 (16.1%) patients. Procalcitonin (PCT) levels were used to diagnose sepsis. The duration of antibacterial therapy (ABT) was based on the determination of PCT and the patient's clinical condition. The decision to prescribe or abstain from ABT should be reviewed within the next 6-24 hours based on the patient's clinical condition and PCT level. These values ​​should also be taken into account in the decision-making process regarding the duration of ABT, as well as the clinical course of the disease. There were no fatalities in the treatment of AP. Purpose of the study. To determine the diagnostic and prognostic significance of procalcitonin in patients with pyogenic liver abscesses. Materials and methods. The results of treatment of 79 patients with pyogenic liver abscesses were analyzed. The mean age of patients was 48.4 ± 4.7 years, with men predominating (62.9%). The inclusion criterion was the presence of pyogenic liver abscesses, the exclusion criteria were cholangiogenic and specific abscesses. The main group consisted of 44 patients who received comprehensive conservative therapy, taking into account antibacterial treatment, the duration of which was determined by determining the level of PСT. Patients in the control group (35 patients) did not differ from the main in age, sex, comorbidities, severity of the disease and the results of microbiological examination, but received conventional ABT. Results.  Carrying out adequate combined antibiotic therapy in patients with AP by determining PKT, along with surgery, reduced the recovery time of patients: 2-3 days normalization of body temperature (t = 5.66176; P <0.000001) and leukocyte formula (t = 8,56860; P <0,000001) patients of the main group compared with control patients Conclusion. Conducting ABT by determining the level of PСT contributed to a probable reduction in the length of stay in the hospital for 3 days (t = 3.95561; P = 0.000116).