Affiliation:
1. Kazan State Medical University; Children's Republican Clinical Hospital
2. Kazan State Medical University
Abstract
The prevalence of inflammatory bowel diseases (IBD) is increasing worldwide. Crohn's disease (CD) and ulcerative colitis (UC) are characterized by chronic progressive course, high frequency of complications, and high risk of surgical treatment. Up to 50% of CD patients die due to its complications, and quarter of these patients require at least one surgery during their lifetime. IBD patients have 8 times higher risk of colorectal and small intestine cancer. IBD diagnosis can be established during childhood in 25% of cases. Early intensified therapy of individual patient groups could significantly reduce complications and surgical treatment rates. However, nowadays there are no reliable prognostic criteria for the unfavorable course of IBD. The aim of this review is to define the most studied IBD serological markers and to evaluate immune reactivation role in CD and UC course in children.
Publisher
Paediatrician Publishers LLC
Subject
Pulmonary and Respiratory Medicine,Pediatrics, Perinatology and Child Health
Reference50 articles.
1. Hammer T, Langholz E. The epidemiology of inflammatory bowel disease: balance between East and West? A narrative review. Dig Med Res. 2020;3:48. doi: https://doi.org/10.21037/dmr-20-149
2. Burisch J, Munkholm P. The epidemiology of inflammatory bowel disease. Scand J Gastroenterol. 2015;50(8):942-951. doi: https://doi.org/10.1097/MOG.0b013e32836229fb
3. Kornienko EA, Khavkin AI, Fedulova EN, et al. Draft recommendations of the russian society of pediatric gastroenterology, hepatology and nutrition on diagnosis and treatment of Crohn's disease in children. Experimental and Clinical Gastroenterology. 2019;(11):100-134. (In Russ). doi: 10.31146/1682-8658-ecg-171-11-100-134
4. Alhasov AB, Bataev SM, Belmer SD, et al. Detskaya gastroenterologiya: National guide. Series “National guides”. Moscow: GEOTAR-Media; 2022. pp. 391-433. (In Russ). doi: https://doi.org/10.33029/9704-6990-3-GAS-2022-1-864
5. Vakhitov TYa, Kononova SV, Demyanova EV, et al. Identification of candidate biomarkers for inflammatory bowel disease using non-targeted serum metabolomics. Pediatric Nutrition. 2022;20(6):21-32. (In Russ). doi: https://doi.org/10.20953/1727-5784-2022-6-21-32
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献