Author:
Birch AJ,Massy-Westropp RA,Moye CJ
Abstract
The general problem of the biosynthesis of
depsides and depsidones is considered. Feeding experiments using sodium acetate
isotopically labelled in the carboxyl group have demonstrated that the mould
Penicillium griseofulvum Dierckx (Raistrick's strain P68) elaborates
2-hydroxy-6-methylbenzoic acid (VII) by the head-to-tail linkage of acetic acid
units in accord with the hypothesis of Birch and Donovan (1953). This
demonstration constitutes the first definite support for the hypothesis based
on bio- chemical experiments.
Cited by
145 articles.
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