Abstract
The four-step synthesis of
2-(5-phenylthiazol-4-yl)benzoic acid (2a), and its 2-amino derivatives (2b),
required for testing as potential plant growth regulators, is described. The
α-bromo ketone (9b)
was conveniently prepared from commercially available 3- benzylidenephthalide
(8) in two steps, and in turn formed the thiazole esters (12) on treatment with
either a mixture of formamide and phosphorus pentasulfide
or thiourea. Hydrolysis of the esters (12) furnished
the above benzoic acids.
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6 articles.
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