Urinary Excretion of Creatine in the Sheep

Abstract

Creatinuria was found in normal rams, wethers, and ewes on ordinary diets. This finding emphasizes the need for caution> in interpreting urine creatine concentration or creatine to creatinine ratios used as diagnostic aids in muscular dys� trophy in sheep. No change in creatine output per 24 hr was observed when the ewes were fasted for 6 days. Values are given for the ratio creatine clearance to creatinine clearance in rams, wethers, and ewes and for creatine clearance in ewes.