Bromination of Pyrimidines: A Simple Inexpensive Method

Abstract

Although the introduction of halogens into the pyrimidine ring has been accomplished numerous times, the methods usually involve either specialised reagents or very aggressive conditions. This communication paper describes the introduction of bromine into position 5 of the pyrimidine ring using common inorganic salts at room temperature. An evaluation of the substituents required for successful reaction is provided.