Effects of high doses of molybdenum and sulphate on the distribution of copper in plasma and in blood of sheep

Author:

Bingley JB

Abstract

Sheep on a daily intake of 120 mg molybdenum and 7.4 g sulphate for 29 months maintained plasma total copper concentrations at twice (P < 0.05) and plasma direct-reacting copper concentrations at 10 times (P < 0.01) the pre-experimental level. Plasma ceruloplasmin levels in these sheep were not significantly increased, but the copper concentration in the red cells was reduced to one-tenth of the normal level (1.0 µg/ml). When the molybdenum dose was progressively diminished, plasma total copper and directreacting copper concentrations remained elevated above the normal until the molybdenum intake was reduced to 12 mg per day. The minimum concentration of copper in the red cells was induced when the molybdenum intake was 96 mg per day. Small amounts of copper detected in the ultrafiltrates of plasma from both treated and untreated sheep were independent of the total plasma concentration. The correlation between non-direct-reacting copper and ceruloplasmin in the plasma, whether determined spectrophotometrically or by its oxidase activity, was high (r = 0.89, P < 0.01). This allowed the use of a regression equation to calculate the non-direct-reacting copper concentration of the plasma. All the copper in the plasma from sheep on a high intake of molybdenum and sulphate could be accounted for in terms of direct-reacting copper, ceruloplasmin copper and ultrafiltrable copper. A significant decrease (P < 0.01) in the copper concentration of the wool was caused by treatment of the sheep with molybdenum and sulphate. At the end of the period the haemoglobin concentration in the blood of the sheep on the continuous high dose of molybdenum and sulphate had fallen 30%, but the weight of the sheep was maintained, and apart from the condition of the wool, no clinical signs of copper deficiency were observed.

Publisher

CSIRO Publishing

Subject

General Agricultural and Biological Sciences

Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3