Effects of a single injection of Flunixin meglumine or Carprofen postpartum on haematological parameters, productive performance and fertility of dairy cattle

Abstract

The objective of the present research was to evaluate the effects of a single injection of Flunixin meglumine (FM) or Carprofen postpartum on haematological indicators, productive performance and fertility of Italian Friesian dairy cattle. In total, 60 cows, including 42 multiparous and 18 primiparous, were assigned to one of the following three treatments: (1) FM (2.2 mg i.m./kg of bodyweight (BW); Meflosyl 50 mg/mL), (2) Carprofen (CA; 1.4 mg s.c./kg of BW; Rymadil 50 mg/mL) or (3) saline (control) at 2.0 mL s.c./45.5 kg of BW. All treatments were administrated by a single injection within 12 h after calving. Individual milk yield was daily recorded during the trial and composition was determined at 7, 14, 21, 28, 35 and 60 days in milk (DIM). BWs were recorded at –21 ± 5 days before calving, and 1, 7, 14, 21, 28, 35 and 60 days after calving before the morning milking. Individual blood samples were collected from each animal for haemato-biochemical evaluation 3 weeks before calving (T0) and then repeated at the following times: within 12 h after calving, immediately before the administration of the anti-inflammatory drug (FM or CA; T1), ~36 h after calving (T2), 4 days after calving (T3) and 11 days after calving (T4). At each sampling time, the rectal temperature and the heart rate were monitored. Body condition score was determined after each sampling time and at 35 and 60 DIM. FM and CA treatments did not influence rectal temperature and heart rate during the first 11 DIM; no differences in overall milk yield, milk composition and dry matter intake were found. BW and body condition score were not affected by treatments throughout the study. Treatments did not affect serum metabolite concentrations of glucose, non-esterified fatty acids, β-hydroxybutyrate, serum urea nitrogen, total protein and albumin. Control cows showed a higher culling rate (P < 0.05) than did the FM- and CA-treated cows (25% vs 15% vs 5% respectively). FM-treated multiparous cows had a significantly (P < 0.05) lower incidence of retained placenta than did control and CA-treated cows (2.3% vs 9.3% vs 14% respectively). Furthermore, a greater percentage of cows pregnant (35% vs 10%) at the first insemination (P < 0.001) in non-steroidal anti-inflammatory drug groups than in control was found. Our findings evidenced that a single injection of FM or CA to non-febrile cows immediately after parturition could positively affect the metabolic adaptation of the cows at the onset of lactation and this aspect can positively influence reproductive performances and the culling rate.