A Modular Visual Model of Energy Metabolism in Human Skeletal Muscle

Abstract

The paper presents a modification of a multi-compartmental mathematical model describing the dynamics of intracellular species concentrations and fluxes in human muscle at rest. A modular representation of a complex model is proposed, which provides the possibility of rapid expansion and modification of the model compartments to account for the complex organization of muscle cells and the limitations of the rate of diffusion of metabolites between intracellular compartments. To illustrate the work of the model, intracellular response in human skeletal muscle to acute aerobic two-legged cycle ergometer training was considered. The model in SBML format is available at http://wiki.biouml.org/index.php/Muscle_metabolism.