Author:
Efremov Y.R.,Proskurina A.S.,Potter E.A.,Dolgova E.V.,Efremova O.V.,Oshchepkov D.Y.,Kolchanov N.A.,Bogachev S.S.
Abstract
The analysis of conditions and possible mechanisms of activation of 96 genes providing a malignant/pluripotent phenotype of Krebs-2 cancer stem cells
have been performed. Three stress factors combined into the single concept of "generalized cellular stress", which are supposed to regulate the expression
of these genes, are determined. Additionally, for these genes, the presence of binding sites for transcription factors that are being activated in response
to factors of generalized cellular stress has been established. The data obtained suggest the existence of a mechanism for the de novo formation of
a pluripotent/stem-like phenotype of tumor cells under conditions of generalized cellular stress.
Publisher
Institute of Mathematical Problems of Biology of RAS (IMPB RAS)
Subject
Applied Mathematics,Biomedical Engineering