Antimicrobial Activity of Proton Salts of 3-(Sulfamoylphenylcarbamoyl) Acrylic Acid Derivatives with Aminopyridine Derivatives

Abstract

In this study, proton transfer salts 9-13 and 14-18 were synthesized from the reaction of (E)-4-oxo-4-(3/4-sulfamoylphenyl)amino)but-2-enoic acid (7 and 8) with 2-aminopyridine (1), 2-amino-3/4/5/6-methylpyridines (2-5) and 3-aminomethylpyridine (6), respectively, by the methods found in the literature. Antimicrobial evaluation of compounds (1-18) has been tested against Enterococcus faecalis (ATCC 29212) (Gram positive), Bacillus subtilis (wild culture), Listeria monocytogenes (ATCC 7644), Staphylococcus aureus (NRRL B-767), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922) (Gram negative) and Candida albicans (ATCC 14053) (yeast) microorganisms. The MIC (Minimum Inhibitory Concentration) values of the 1-18 were compared with the antibacterial reference compounds Levofloxacin Cefepime, Vancomycin and the antifungal compound Fluconazole. Compounds 5 (7.80 µg/mL) for B. subtilis, 1, 3-6, 8-13, 15, 17 and 18 (62.50 µg/mL) for E. faecalis, 1, 3-12, 15, 17 and 18 (62.50 µg/mL) for S. aureus, 16 (7.80 µg/mL) for E. Coli, 3, 9, 10, 13, 15 and 17 (31.25 µg/mL) for L. monocytogens, 4 (15.60 µg/mL) for P. aeruginoa and 9 (15.60 µg/mL) for C. albicans the best activity are observed.