ANTIBACTERIAL, ANTIFUNGAL, ANTIBIOFILM, ANTIOXIDANT, AND ANTICANCER PROPERTIES OF METHANOL EXTRACTS OF SOME ACANTHOLIMON BOISS (PLUMBAGINACEAE) SPECIES
Author:
BOSTANCI Maside Temiz1ORCID, BÜLBÜL Ali Savaş2ORCID, UYGUN Cihangir3ORCID, BEKMEZCİ Muhammed4ORCID, BAYAT Ramazan4ORCID, ŞEN Fatih1ORCID
Affiliation:
1. KUTAHYA DUMLUPINAR UNIVERSITY 2. BAYBURT ÜNİVERSİTESİ 3. Akedaş İlköğretim okulu 4. KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ
Abstract
Therapeutic properties of plants have been used since the existence of mankind. To benefit from this feature, the discovery of the active components of plants has gained momentum today. One of these plant species is Acantholimon Boiss. This plant extract has antifungal, antimicrobial, and anticancer properties. In this article, antimicrobial, antifungal and antioxidant capacities and antibiofilm properties of Acantholimon Boiss plant extract on 15 bacterial and 2 fungal species were evaluated. Antimicrobial properties were evaluated by Agar Well Diffusion method. It was observed that the plants formed a zone diameter of 12-18 cm. Minimum Inhibition Concentration (MIC) and Minimum Bactericidal Concentration (MBC) tests were used to determine the minimum active property. Biofilms of almost all bacteria were reduced by 10-50% by Acantholimon species at doses of 8 mg/ml-16 mg/ml. For MCF-7 cells, the IC50 values for A. acerosum subsp. brachystachyum (Boiss. ), A. acenum var. balansae, A. armenum var. balansae and A. kotschyi were 0.143 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml and 0.107 mg/ml, respectively. The same doses did not show a cytotoxic effect on HUVEC cell lines. With this article, it has given important results in terms of having a wide range of bacterial studies and examining its activities in fungi and cell lines. These findings suggest that extracts of Acantholimon Boiss species may be a potential source of natural medicines and antibacterial, antifungal, antibiofilm, antioxidant, and anticancer activities may support their therapeutic use.
Publisher
Kütahya Dumlupinar Üniversitesi
Reference27 articles.
1. [1] Jaleel, C.A., Sathiya, S., Karthikeyan, B., Jaleel, A., Azooz, M.M., and Iqbal, M., (2008). Antibiogram of Catharanthus roseus Extracts. Global Journal of Molecular Sciences. 3 (1), 1–07. 2. [2] Saroya, A.S., (2011). Herbalism, phytochemistry and ethnopharmacology. Herbalism, Phytochemistry and Ethnopharmacology. 1–430.
[3] Bagetta, G., (2012). Herbal medicines : development and validation of plant-derived medicines for human health. 478. 3. [4] Saad, B., Zaid, H., Shanak, S., and Kadan, S., (2017). Introduction to Medicinal Plant Safety and Efficacy. Anti-Diabetes and Anti-Obesity Medicinal Plants and Phytochemicals. 21–55. 4. [5] Pandey, M., Debnath, M., Gupta, S., and Chikara, S.K., (2011). Phytomedicine: An ancient approach turning into future potential source of therapeutics. Journal of Pharmacognosy and Phytotherapy. 3 (3), 27–37. 5. [6] Kubitzki, K., (1993). Plumbaginaceae. Flowering Plants, Dicotyledons. 523–530.
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