The Naked Mole-Rat as a Model for Healthy Aging-Reference-Cited by-同舟云学术

The Naked Mole-Rat as a Model for Healthy Aging

Published:2023-02-15 Issue:1 Volume:11 Page:207-226
ISSN:2165-8102
Container-title:Annual Review of Animal Biosciences
language:en
Short-container-title:Annu. Rev. Anim. Biosci.

Author:

Oka Kaori¹,Yamakawa Masanori²,Kawamura Yoshimi¹,Kutsukake Nobuyuki²³,Miura Kyoko¹⁴

Affiliation:

1. Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan;, ,

2. Department of Evolutionary Studies of Biosystems, Sokendai (The Graduate University for Advanced Studies), Kanagawa, Japan;,

3. Research Center for Integrative Evolutionary Science, Sokendai (The Graduate University for Advanced Studies), Kanagawa, Japan

4. Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan

Abstract

Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and resistance to age-related functional decline/diseases. Specifically, they do not display increased mortality with age, maintain several physiological functions until nearly the end of their lifetime, and rarely develop cancer and Alzheimer's disease. NMRs live in a hypoxic environment in underground colonies in East Africa and are highly tolerant of hypoxia. These unique characteristics of NMRs have attracted considerable interest from zoological and biomedical researchers. This review summarizes previous studies of the ecology, hypoxia tolerance, longevity/delayed aging, and cancer resistance of NMRs and discusses possible mechanisms contributing to their healthy aging. In addition, we discuss current issues and future perspectives to fully elucidate the mechanisms underlying delayed aging and resistance to age-related diseases in NMRs.

Publisher

Annual Reviews

Subject

General Veterinary,Genetics,Animal Science and Zoology,Biotechnology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-animal-050322-074744

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