LIVE ATTENUATED VARICELLA VACCINE-Reference-Cited by-同舟云学术

LIVE ATTENUATED VARICELLA VACCINE

Published:1996-10 Issue:1 Volume:50 Page:59-100
ISSN:0066-4227
Container-title:Annual Review of Microbiology
language:en
Short-container-title:Annu. Rev. Microbiol.

Author:

Arvin Ann M.¹,Gershon Anne A²

Affiliation:

1. Department of Pediatrics and Microbiology/Immunology, Stanford University Medical Center, Stanford, Menlo Park, California 94305

2. Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032

Abstract

Varicella-zoster virus (VZV) is a ubiquitous human pathogen that causes varicella, commonly called chicken pox; establishes latency; and reactivates as herpes zoster, referred to as shingles. A live attenuated varicella vaccine, derived from the Oka strain of VZV has clinical efficacy for the prevention of varicella. The vaccine induces persistent immunity to VZV in healthy children and adults. Immunization against VZV also has the potential to lower the risk of reactivation of latent virus. The varicella vaccine may eventually reduce or eliminate herpes zoster, which is a serious problem for elderly and immunocompromised individuals.

Publisher

Annual Reviews

Subject

Microbiology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.micro.50.1.59

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