Affiliation:
1. Departments of 1Anesthesiology and 2Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794;
Abstract
▪ Abstract Pleckstrin homology (PH) motifs are approximately 100 amino-acid residues long and have been identified in nearly 100 different eukaryotic proteins, many of which participate in cell signaling and cytoskeletal regulation. Despite minimal sequence homology, the three-dimensional structures are remarkably conserved. This review gives an overview of the PH domain architecture and examines the best-studied examples in an attempt to understand their function.
Subject
Structural Biology,Biophysics
Cited by
254 articles.
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