1. Division of Yeast Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;
2. Laboratory of Gene Regulation, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX;
3. Department of Biochemistry and Genetics, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK;
4. (corresponding author) Division of Yeast Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;