Author:
Ren Ya,Yang Xue,Ma Zhengjiang,Sun Xin,Zhang Yuxin,Li Wentao,Yang Han,Qiang Lei,Yang Zezheng,Liu Yihao,Deng Changxu,Zhou Liang,Wang Tianchang,Lin Jingsheng,Li Tao,Wu Tao,Wang Jinwu
Abstract
Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in drug screening, disease modeling, and regenerative repair of tissues and organs. However, the construction of organoids currently faces numerous challenges, such as breakthroughs in scale size, vascularization, better reproducibility, and precise architecture in time and space. Recently, the application of bioprinting has accelerated the process of organoid construction. In this review, we present current bioprinting techniques and the application of bioinks and summarize examples of successful organoid bioprinting. In the future, a multidisciplinary combination of developmental biology, disease pathology, cell biology, and materials science will aid in overcoming the obstacles pertaining to the bioprinting of organoids. The combination of bioprinting and organoids with a focus on structure and function can facilitate further development of real organs.
Publisher
Whioce Publishing Pte Ltd
Subject
Industrial and Manufacturing Engineering,Materials Science (miscellaneous),Biotechnology
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献