Influence of Saccharomyces cerevisiae to ameliorate adverse effects of ochratoxin on biochemical profile and immune response in broiler chickens

Abstract

To establish the ochratoxicosis ameliorating efficacy of dietary Saccharomyces cerevisiae (SC), day-old broiler chicks (240) were divided into 6 treatment groups (T1, control (basal diet); T2, T1 + 200 ppb OTA; T3, T1 + 0.05% SC; T4, T1 + 0.1% SC; T5, T2 + 0.05% SC and T6, T2 + 0.1% SC). Each diet was fed to 5 replicated groups of 8 birds each from 1 to 42 days of age. The total serum protein and haemoglobin (Hb) in T2 and T5 were lower than that of control (T1). The serum protein and Hb content in group T6 was higher than that of T2 and statistically similar to that of control. The serum uric acid, creatinine, ALP, SGOT, SGPT and H/L ratio in ochratoxin fed group (T2) was higher than that of T1. The serum uric acid, creatinine, ALP, SGOT, SGPT and H/L ratio in T6 was lower than that of T2 and statistically similar to that of T1. The CMI and HA titre value in ochratoxin fed group (T2) was lower than that of T1. The CMI and HA titre value in T5 and T6 was lower than T1 but higher than T2. It was concluded that ochratoxin contamination at 200 ppb level in broiler diet altered the biochemical parameters and immune response. Inclusion of Saccharomyces cerevisiae at 0.1% level to the ochratoxin contaminated diet ameliorated the adverse effects of ochratoxicosis on biochemical parameters and immune response of broiler chickens.