Short review of the biomedical properties and application of magnesium alloys for bone tissue bioengineering-Reference-Cited by-同舟云学术

Short review of the biomedical properties and application of magnesium alloys for bone tissue bioengineering

Published:2019-08-11 Issue:2 Volume:18 Page:274-286
ISSN:1819-3684
Container-title:Bulletin of Siberian Medicine
language:
Short-container-title:Bûll. sib. med.

Author:

Khlusov I. A.¹^ORCID,Mitrichenko D. V.²,Prosolov A. B.²,Nikolaeva O. O.²,Slepchenko G. B.³,Sharkeev Yu. P.⁴^ORCID

Affiliation:

1. Siberian State Medical University; Research and Production Company SINTEL LLC; National Research Tomsk Polytechnic University

2. Research and Production Company SINTEL LLC

3. National Research Tomsk Polytechnic University

4. National Research Tomsk Polytechnic University; Institute of Strength Physics and Materials Science of SB RAS

Abstract

Aim: to review current scientific literature concerning the main advances and problems of magnesium (Mg) alloys for traumatology and orthopedics. Methodology of the study. Analytical review based the comprehensive investigation of public scientific and technological sources. Results of the study. Modern knowledge about classification, in vitro and in vivo biodegradation, biomechanics, local and general biocompatibilities, clinical efficacy, and hazards of infectious complications in conditions of osteosynthesis with implants made of Mg alloys with or without protective (anticorrosion and antimicrobial) coatings is presented. Conclusion. Fast degradation and a risk of periprosthetic infection strongly limit clinical application of implants made of Mg and its alloys. Development of novel Mg alloys and their modification by incorporating antimicrobial elements into their body or protective coating is a promising direction to control biomedical characteristics of Mg alloys.

Publisher

Siberian State Medical University

Subject

Molecular Medicine

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