Affiliation:
1. Almazov National Medical Research Centre of the Ministry of Health of Russian Federation
2. Joint Stock Company “Generium”, Test Center “Center for Preclinical Research”
Abstract
The review is devoted to the current assesment of the role of nitric oxide and inducible NO-synthase in physiological and pathological conditions. The inducible NO-synthase gene expression induction and post-transcriptional regulation of its activity are considered. Data on endogenous inducible NO-synthase inhibitors of are given. An analysis of the clinical trials aimed at studying the clinical efficacy of NO synthase inhibitors was carried out.
Publisher
Cardiology Research Institute
Subject
Cardiology and Cardiovascular Medicine,Public Health, Environmental and Occupational Health,Radiology, Nuclear Medicine and imaging,Medicine (miscellaneous),Internal Medicine
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