Affiliation:
1. Privolzhsky Research Medical University MH RF
2. Privolzhsky Research Medical University MH RF;
Nizhny Novgorod Regional Clinical Hospital named after Semashko N.A.
Abstract
The article provides a review of the literature on the possibilities of using various indices of insulin resistance in type 2 diabetes (T2DM) treatment. The main mechanisms of insulin resistance and its role in the formation of type 2 diabetes mellitus and other metabolic disorders are described. The main indices of insulin resistance, used in real clinical practice nowadays, are considered. Methods of their calculation are given. The effect of metformin and incretin active medications on insulin resistance is described. It was shown that the combination of these medications improves tissue sensitivity to insulin in patients with T2DM. Standard indicators for assessing glycemic control, such as fasting glucose and glycosylated hemoglobin (HbA1c), do not reflect the patient’s lipid metabolism. The use of insulin resistance assessment indices in patients with type 2 diabetes mellitus allows both, exercising glycemic control, and the metabolic disorders, often associated with carbohydrate metabolism disorders, monitoring. Using insulin resistance indices, it is possible to select the optimal treatment regimen for type 2 diabetes mellitus for a particular patient, to predict and evaluate the effectiveness of treatment in dynamics. Simple, generally available laboratory indicators and anthropometric data are used to calculate the indices of insulin resistance, and they are easy to measure. In this regard, the use of insulin resistance indices is possible in routine clinical practice.
Publisher
Medical Informational Agency Publishers
Reference39 articles.
1. International Diabetes Federation. IDF Diabetes Atlas, 9th edn. Brussels, Belgium: 2019. [Electronic resource]. URL: https://www.diabetesatlas.org.
2. del Prato S, Indovina F, Falcetta P. Type 2 Diabetes Mellitus. From the start — combination therapy. Diabetes Mellitus. [Saharnyj diabet]. 2018;21(5):386–394. (in Russian)
3. Mendrick D.L., Diehl A.M., Topor L.S., Dietert R.R., Will Y., La Merrill M.A. et al. Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic. Toxicol. Sci. 2018;162(1):36–42.
4. Bellia A., Giardina E., Lauro D., Tesauro M., Di Fede G., Cusumano G. et al. «The Linosa Study»: Epidemiological and Heritability Data of the Metabolic Syndrome in a Caucasian Genetic Isolate. Nutr. Metab. Cardiovasc. Dis. 2009;19(7):455–61.
5. Lehtovirta M., Kaprio J., Forsblom C., Eriksson J., Tuomilehto J., Groop L. Insulin Sensitivity and Insulin Secretion in Monozygotic and Dizygotic Twins. Diabetologia. 2000;43(3):285–93.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献