Neuroinflammatory Part of the Systemic Inflammatory Process in the Development of Neurodegenerative Conditions
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Published:2023-10-23
Issue:5
Volume:21
Page:17-24
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ISSN:2618-6667
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Container-title:Psikhiatriya
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language:
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Short-container-title:Psychiatry
Author:
Generalov V. O.1ORCID, Obodzinskaya T. E.1ORCID, Sadykov T. R.1ORCID, Yugay A. M.1ORCID, Aleksandrenkova A. A.1ORCID, Larionov G. V.1ORCID, Niculina L. V.1ORCID
Affiliation:
1. Medical Center “Planeta Med”
Abstract
Background: neurodegenerative processes are prognostically dramatic conditions. They are actively studied by both neurologists and psychiatrists. Nosological forms are diverse and include regressive autism, dementia, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, progressive epilepsy of infancy and childhood, generalized hyperkinesis, Tourette’s syndrome and many other conditions that are common to progressive neurological deficit, loss of cognitive functions, the appearance of nonspecific symptoms of brain irritation (epileptic seizures, hyperkinesis, dystonic states, stereotypes, psychotic episodes and other symptoms). Despite many ongoing studies the treatment of the described conditions is limited to temporary, incomplete and pharmacologically dependent relief of symptoms, since the problem of the etiopathogenesis of these conditions remains open. The aim of review is to present current immunological concepts of pathogenesis of neurodegenerative diseases. Material and method: using keywords “neuroinflammation, neurodegeneration, multiple sclerosis, Parkinson disease, epilepsy, parasitosis, microbiota” selected relevant scientific publications in domestic and international databases. Conclusion: recent advances in neuroimmunology show a significant role of neuroinflammation in the triggering and development of neurodegenerative processes, some of which are autoimmune in nature, which is confirmed by the indicators of immunity intensity introduced into clinical practice and by the detected antibody titers to brain tissues. In recent decades in a series of scientific works attention has been paid to the study of infectious agents detected in the immunological screening of patients with neurodegeneration, however, these data are fragmented and contradictory, and therefore are ignored by the medical community. This review presents a modern view of the etiopathogenesis of neurodegenerative diseases from the point of view of the summative antigenic burden, assessment of the immunological potential, homeostatic resource, and compensatory capabilities of the human body, which as a result can become a starting point for proposing new therapeutic strategies for the treatment of these intractable diseases.
Publisher
Medical Informational Agency Publishers
Subject
Biological Psychiatry,Psychiatry and Mental health,Clinical Psychology
Reference43 articles.
1. Cova I, Markova A, Campini I, Grande G, Mariani C, Pomati S. Worldwide trends in the prevalence of dementia. J NeurolSci. 2017;379:259–260. doi: 10.1016/j.jns.2017.06.030 2. Adler CH, Beach TG, Hentz JG, Shill HA, Caviness JN, Driver-Dunckley E, Sabbagh MN, Sue LI, Jacobson SA, Belden CM, Dugger BN. Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology. 2014;83(5):406–412. doi: 10.1212/WNL.0000000000000641 3. Alafuzoff I, Ince PG, Arzberger T, Al-Sarraj S, Bell J, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Parchi P, Parkkinen L, Patsouris E, Roggendorf W, Rozemuller A, Stadelmann-Nessler C, Streichenberger N, Thal DR, Kretzschmar H. Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol. 2009;117(6):635–652. doi: 10.1007/s00401-009-0523-2 4. Alafuzoff I, Thal DR, Arzberger T, Bogdanovic N, Al-Sarraj S, Bodi I, Boluda S, Bugiani O, Duyckaerts C, Gelpi E, Gentleman S, Giaccone G, Graeber M, Hortobagyi T, Höftberger R, Ince P, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Pikkarainen M, Revesz T, Rozemuller A, Seilhean D, Schulz-Schaeffer W, Streichenberger N, Wharton SB, Kretzschmar H. Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. Acta Neuropathol. 2009;117(3):309–320. doi: 10.1007/s00401-009-0485 5. Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease--a double-edged sword. Neuron. 2002;35(3):419–432. doi: 10.1016/s0896-6273(02)00794-8
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