Photodynamic therapy for periprosthetic joint infection

Author:

Guseynov A. I.1ORCID,Baranov А. V.2ORCID,Radzhabov A. A.1ORCID,Derbenev V. A.2ORCID,Karandashov V. I.2ORCID,Alexandrova N. P.3ORCID

Affiliation:

1. Hospital for War Veterans N 2, Department of Moscow Healthcare; Skobelkin State Scientifi c Center of Laser Medicine, FMBA of Russia

2. Skobelkin State Scientifi c Center of Laser Medicine, FMBA of Russia

3. Moscow Scientifi c-Practical Center of Medical Rehabilitation, Restorative and Sports Medicine, Department of Moscow Healthcare

Abstract

Introduction. The increase in the number of patients with joint and hip diseases is an actual problem in the clinical medicine. Objective: to improve outcomes of the combined surgical treatment of patients with deep periprosthetic infection (PPI) by developing and improving surgical techniques using spacers and laser technologies.Material and methods. Thirty-five patients with suppurated large joints as a complication after their replacement were examined and treated. In 9 (25.7 %) patients, PPI developed within 3–12 months after the primary arthroplasty. Twenty (57.1 %) patients developed PPI within 1–2 years after the surgery. In 4 (11.4 %) cases, suppuration in the endoprosthetic area developed in 2–3 years, and in 2 (5.7 %) patients – in 3–3.5 years. The age of the patients was 47–70 years. The main group consisted of 20 patients, the control group – of 15 patients. Patients from the main group had laser photodynamic therapy (PDT) session after the removal of endoprosthetic elements and devitalized tissues.Results. Patients from the main group had uneventful postoperative course – less pain syndrome, rapid resolution of the infl ammatory process, wound healing by the primary tension.Conclusion. Application of a new intraoperative PDT technique, developed by the authors, promotes rapid resolution of purulent-infl ammatory process and better healing of postoperative wounds by primary tension.

Publisher

Skobelkin State Scientific Center of Laser Medicine

Subject

General Medicine

Reference12 articles.

1. Artyukh V.A., Bozhkova S.A., Kochish A.Yu. Diagnosis and treatment of periprosthetic hip infection. Guide to hip surgery; R.M. Tikhilov, I.I. Shunnyakov (eds). 2015; 2: 208–257. [In Russ.].

2. Tolstykh P.I. Theoretical and practical aspects of photodynamic therapy of wounds of various origins. Prolegomena; Tolstykh P.I., Lutsevich O.E. (eds). Moscow: Altair, 2012; 249 p. [In Russ.].

3. Baitov V.S., Ganchukov E.B. Infectious complications in total knee arthroplasty. Modern problems of science and education. 2017; 5. [In Russ.].

4. Campbell M.D. Fighting infection in total knee arthroplasty; In: Revision knee arthroplasty: A guide for doctors; ed. D.J. Jacofsky, E.K. Headley. Moscow: GEOTAR-Media, 2015; 320 p. [In Russ.].

5. Radzhabov A.A., Derbenev V.A., et al. Antibacterial photodynamic therapy of purulent wounds of soft tissues. Laser medicine. – 2017; 21 (2): 24–26. [In Russ.].

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