Outcomes after intraoperative photodynamic therapy in the combined treatment of locally advanced colon cancer

Abstract

   Purpose. To study outcomes after the combined treatment of locally advanced colon cancer with intraoperative photodynamic therapy.   Materials and methods. 35 patients with locally advanced colon cancer were included in the trial. Patients from the main group (n = 17) had intraoperative photodynamic therapy in combination with elective surgery. Patients from the control group (n = 18) had only surgical treatment. For photodynamic therapy, photosensitizer Photolon and “Lakhta-Milon” diode laser with wavelength 662 nm and power up to 2.5 W were used. Laser light was delivered via a quartz polymer fiber with diameter 600 microns.   Results and discussion. Better positive immediate and long-term outcomes were registered in patients with locally advanced colon cancer from the main group, if to compare with the control group (length of hospital stay, number of remissions, relapses and mortality).   Conclusion: Intraoperative photodynamic therapy improves outcomes after the combined treatment of patients with locally advanced colon cancer.