Author:
Todorov Sergey S.,Todorov(Jr.) Sergey S.,Deribas Victoria Yu.,Kazmin Andrey S.,Fomchencova Yulia M.
Abstract
Аbstract. Neoplasia of the small intestine are extremely rare. A special place is occupied by tubular adenocarcinomas of the small intestine with a neuroendocrine component, the intravital diagnosis of which is difficult. Materials and methods. The paper presents a clinical observation of a 61-year-old patient who after resection of the small intestine was found to have tubuLar adenocarcinoma with a neuroendocrine component. Results. Morphoimmunohistochemical examination of the tumor revealed tubular adenocarcinoma with a neuroendocrine component (chromogranin A+, NSE+, aLcian+) with invasion into the subserous base. Conclusions. Tubular adenocarcinoma of the small intestine with a neuroendocrine component is a rare neoplasm of the gastrointestinal tract. In vivo pathoanatomical diagnosis of an intestinal tumor should include morphological, histochemical, immunohistochemical studies with the detection of tumor neuroendocrine cells and assessment of malignant potential.
Publisher
Volgograd State Medical University
Subject
Anesthesiology and Pain Medicine
Reference10 articles.
1. Пинский С.Б., Белобородов В.А., Батороев Ю.К., Дворниченко В.В. Нейроэндокринные опухоли желудочнокишечного тракта (сообщение 4) нейроэндокринные опухоли тонкой кишки // Сибирский медицинский журнал (Иркутск). 2015. Т. 133 (2). С. 10-16.
2. Synchronous multiple carcinoma with small intestine and pulmonary neuroendocrine involvement
3. Programmed cell death ligand-1 expression in gastro-enteropancreatic neuroendocrine tumors / E. Oktay, G.D. Yalcin, S. Ekmekci [et al.] // J BUON. 2019. Vol. 24 (2). P. 779-790.
4. PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma–paraganglioma origin
5. Mixed adenoneuroendocrine carcinoma of the ampulla: two case reports / Z. Huang, W.D. Xiao, Y. Li [et al.] // World J. Gastroenterol. 2015. Vol. 21 (7). P. 2254-2259. doi: 10.3748/ wjg.v21.i7.2254.