COMPARATIVE PHARMACOGNOSTIC RESEARCH OF CENTAUREA SCABIOSA L. WILD-GROWING AND CULTI-VATED IN THE CONDITIONS OF TOMSK

Abstract

The purpose of this study is: on the basis of a comparative study of the biological characteristics and chemical composition of Centaurea scabiosa L. wild-growing and cultivated, to assess the prospects for its introduction into culture as an additional source of raw materials for the anthelmintic drug development. It has been established that the Centaurea scabiosa L. cultivated under the conditions of the Tomsk city in terms of developmental phenology is close to a wild-growing plant. The vegetative organs ratios of wild-growing and cultivated plants were determined: leaves constitute 10% and 24%; baskets – 37% and 24%; stems up to 0.5 cm of thick –18% and 20%; stems with a thickness of more than 0.5 cm – 34% and 31%, respectively (beginning of flowering phase). The cultivated Centaurea scabiosa L. is comparable to a wild-growing plant according to the sesquiterpene lactones content in separated organs. The sesquiterpene lactones maximum amount accumulates in the budding phase, decreases slightly at the beginning of flowering, and significantly decreases at the mass flowering phase. The Centaurea scabiosa L. harvesting periods (the leafiest shoots with a stem diameter of not more than 0.5 cm) are experimentally substantiated – the phase of flowering onset.