Solitary Fibrous Tumor of the Liver Disguised as Hepatocellular Cancer

Author:

Ruzavin Vladimir SemenovichORCID,Gorlenko Cyrill LeonidovichORCID,Shirokov Vadim SergeevichORCID,Kalinin Dmitry ValerievichORCID,Goncharov Anton BorisovichORCID,Kovalenko Yuri AlekseevichORCID,Stepanova Yulia AlexandrovnaORCID,Gurmikov Beslan NuralievichORCID

Abstract

Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin characterised by NAB2 and STAT6 genes fusion. SFT occurs in one of 300.000 patients who seek medical attention. Incidence rate of liver SFT is unavailable due to a minor number of existing observations. In most cases, diagnosis of SFT is incidental. Yet, in 5% of cases, it manifests as paraneoplastic syndromes. Differential diagnosis using CT and MRI is complicated due to unspecific pattern of the neoplasm. This paper presents a clinical case of a 58-year-old patient who applied for a consultation at A.V. Vishnevsky National Medical Research Center of Surgery. Due to non-specificity, the laboratory and instrumental examination findings did not allow making a correct diagnosis at the preoperative stage. Histological examination findings helped to finally diagnose solitary fibrous tumor. Based on the data obtained, we can draw a conclusion about the imperfection of existing diagnostic options and the need to identify specific criteria for solitary fibrous tumor diagnosis.

Publisher

VSMU N.N. Burdenko

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