Morphofunctional Changes in Peripheral Immune Organs in Space Flight and Weightlessness Modeling-Reference-Cited by-同舟云学术

Morphofunctional Changes in Peripheral Immune Organs in Space Flight and Weightlessness Modeling

Published:2021-12-16 Issue:4 Volume:10 Page:56-67
ISSN:2225-7357
Container-title:Journal of Anatomy and Histopathology
language:
Short-container-title:Žurnal anatomii i gistopatologii

Author:

Kordenko A. A.¹,Shishkina V. V.²,Kordenko A. N.³,Atyakshin D. A.⁴,Sokolov D. A.²,Kvaratskheliya A. G.²

Affiliation:

1. Voronezh State Pedagogical University; N.N. Burdenko Voronezh State Medical University

2. N.N. Burdenko Voronezh State Medical University

3. Voronezh State Pedagogical University

4. N.N. Burdenko Voronezh State Medical University; People’s Friendship University of Russia

Abstract

Currently, there are many studies devoted to the problems of immunity in space flights. It has been proven that both short-term and long-term stay in space significantly reduces the immune function of the body. There are cases of the development of infectious diseases in astronauts during the flight, there is evidence of an increase in the activity of viruses and microorganisms that can affect the health of crew members. In the light of the upcoming expedition to Mars, it is especially important to study exactly what changes in the immune system can be triggered by prolonged stay in zero gravity and other factors of space flight and what preventive measures can help preserve the health of astronauts both during the flight itself and after its completion. The state of the immune system in space has been studied at various levels, from molecular to organ. There was a change in the morphological parameters of the immune system organs, violations of the ratio of their morpho-functional zones, and cellular composition. Various disorders in signaling pathways of differentiation, activation and death of immune system cells are shown. One of the most studied topics is the decrease in the activity of T-lymphocytes recorded by many researchers, however, even in this matter, the mechanisms of the violations occurring and their connection with the conditions of space flight have not been fully clarified. The relevance of methods for modeling microgravity conditions, such as various types of hanging, rotation on a clinostat, and immobilization is due both to their greater availability for research compared to space flights, and the importance of studying the role of various factors associated with flight in changes occurring in the human and animal bodies. This article presents an overview of publications devoted to a wide range of issues related to the state of the immune system in space flights and ground simulation conditions and attempts to combine the results of various levels of research – molecular, cellular and morphological.

Publisher

VSMU N.N. Burdenko

Subject

General Earth and Planetary Sciences,General Environmental Science

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